Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR
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چکیده
منابع مشابه
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Holoprosencephaly (HPE), the most common developmental defect of the forebrain, is caused by a failure to delineate the midline. HPE occurs in sporadic and inherited forms, and even HPE in pedigrees is characterized by variable expressivity. Point mutations and deletions were found in SHH, ZIC2, SIX3 and TGIF genes in about 30% of the genetic cases. HPE is now believed to be a multihit patholog...
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ژورنال
عنوان ژورنال: Genomics
سال: 2010
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2010.02.003